Important Safety Information for Sermorelin Injections

The most common side effects of Sermorelin include:

  • Pain, redness, or irritation at the injection site

  • Face or neck flushing

  • Headache

  • Nausea

Side effects are usually mild and often go away on their own within a week or two.

Potential drug interactions

Sermorelin has no known major drug interactions, but may have the following interactions with certain drugs:

  • Glucocorticoids (prednisone) - May blunt growth hormone (GH) release

  • Oral estrogens - May increase IGF-1 resistance

  • Insulin or sulfonylureas - May alter glycemic control

  • Somatostatin analogs - May antagonize Sermorelin’s effects

  • Dopamine antagonists - May disrupt human growth hormone (HGH) regulation

  • GABAergic meds - May reduce pulsatility of HGH release

  • Beta blockers (clonidine) - May decrease the effectiveness of Sermorelin

  • Other secretagogues/peptides - May result in unsafe levels of HGH

Other important safety information

Sermorelin is only for patients who are at least 30 years old. Patients under 30 should explore other longevity solutions.

Your prescriber may ask you for additional information if you have one of the following conditions:

  • Hypothyroidism - Untreated hypothyroidism can impair a patient’s growth hormone (GH) response. Patients with hypothyroidism may be asked to show that their condition is treated and managed

  • Hyperglycemia or diabetes - Taking Sermorelin with untreated hyperglycemia or diabetes may further impair glycemic control. Patients with hyperglycemia or diabetes may be asked to show that their condition is treated and managed

Sermorelin should not be used by anyone with moderate to severe liver dysfunction or kidney disease.

Do not use Sermorelin if you have an active cancer, or if you have had cancer within the last two years. 

Do not use Sermorelin if you are pregnant, breastfeeding, or planning to become pregnant or breastfeed. If you become pregnant while taking Sermorelin, consult your prescriber before continuing with your next dose.

Though rare, allergic reactions to Sermorelin are still possible. If you notice any shortness of breath or swelling around your face, tongue, or throat after using Sermorelin, stop use and contact emergency services right away. Mild allergic reactions around the injection site are normal and not cause for emergency.

As with any prescription medication, the dose prescribed is for you and you alone. Do not, under any circumstances, allow anyone else to use your Sermorelin.